Beilstein J. Org. Chem.2012,8, 2142–2148, doi:10.3762/bjoc.8.241
-Galf-containing glycoconjugates, the mechanisms by which α-D-Galf units are incorporated remain unclear. Penicilliumvarians is a non-pathogenic fungus that produces varianose, a polysaccharide containing both α- and β-D-Galf units, which can be used as a model for biosynthetic studies on α-D-Galf
; glucosylgalactofuranose; glycosylaldonolactone; Penicilliumvarians; varianose; Introduction
Carbohydrates are involved in a wide range of biological processes; they play important roles in host–pathogen interactions and in the immune response, where protein–glycan interactions mediate a variety of biological processes
, establishing the connection between the glycan structure and its biological function, a discipline called functional glycomics, is one of the most challenging areas nowadays and requires a broad interdisciplinary approach.
Penicilliumvarians elaborates an unusual polysaccharide called varianose [3] that